Gene Expression Chromosomal Correlations in Tumors of Mesodermal Origin: The Case of Rhabdomyosarcoma and Acute Lymphoblastic Leukemia

Abstract-since the advent of high throughput methodologies, like microarrays, the load of genomic data has increased geometrically and along with that the need for computational methods which will interpret these data. In the present work we have studied the common gene expression patterns between two tumor cell types of mesodermal origin. In particular, we have attempted to find causal relations between gene expression levels with respect to chromosomal location. We have found that several genes manifested significant relations, using regression analysis and as such they could pose interesting targets for further investigations. This type of analysis can lead to the understanding of the common mechanisms that transform physiological cells to malignant, as well as it reveals a new holistic way to understand the dynamics of tumor onset as well as the mechanistic of oncogenic drivers. Such approaches could prove to be useful in the prediction of genomic targets that could be further studied in order to unravel the mechanics of tumor ontogenesis.

Keywords-Acute Lymphoblastic Leukemia, Chromosomal correlations, Mesoderm, Microarrays, Rhabdomyosarcoma.

Click here to Download Full Paper
Gene Expression Chromosomal Correlations in Tumors of Mesodermal Origin: The Case of Rhabdomyosarcoma and Acute Lymphoblastic Leukemia

AD Publications is a rapidly growing academic publisher in the fields of Engineering, Medical-Health, Environmental Science and Agriculture Research. AD Publications is a registered organization broad-based open access and publishes most exciting researches with respect to the subjects of our journals. The Journals is being indexed and abstracted by all major global current awareness and alerting services. The organization aims at undertaking, co- coordinating and promoting research and development. It provides professional and academic guidance in the field of basic education, Higher Education as well in the Technical Education. Our Aims is to Promote and support, High Quality basic, Scientific Research and development in fields of Engineering, Medical-Health, Environmental Science and Agriculture Research and to Generate Public awareness, provide advice to scholar's researchers and communicate research outcomes.

Some Important Links About Research Journal International Journal Agriculture Journal Medical Journal Environmental Journal Engineering Journal

Comments

Popular posts from this blog

Applied Biotechnology: Isolation and Detection of an Efficient Biosurfactant from Pseudomonas sp. Comparative Studies against Chemical Surfactants

A novel framework for a pull oriented product development and planning based on Quality Function Deployment

Nonlinear Dynamic Time History Analysis of Multistoried RCC Residential G+23 Building for Different Seismic Intensities